Journal: Journal of hematology & oncology
This study analyzed clonal hematopoiesis of indeterminate potential (CHIP) and its progression to hematologic malignancies (HM) in a large, racially diverse cohort of over 245,000 individuals from the All of Us Research Program.
Key findings include:
- Over 10,000 CHIP driver mutations were identified in nearly 9,500 participants.
- Significant racial disparities were found: African American individuals had higher CHIP prevalence and distinct mutation patterns compared to White Americans.
- CHIP was confirmed as a risk factor for HM, especially myeloid malignancies, with ancestry influencing the specific subtype.
- African Americans showed a stronger association between CHIP and myeloproliferative neoplasms.
These results emphasize the importance of incorporating ancestry into CHIP risk assessment and HM prevention strategies.