Journal: Nature reviews. Urology
The publication reviews the evolving treatment landscape for localized muscle-invasive bladder cancer.
Traditionally, this condition has been managed with neoadjuvant chemotherapy followed by open radical cystectomy. However, recent advances aim to reduce postoperative morbidity and improve outcomes.
Key innovations include:
- Enhanced imaging
- Prehabilitation
- Perioperative care
- Robotic surgery
- Organ-sparing approaches
Bladder preservation strategies—either after a complete clinical response or following trimodal therapy—are gaining traction.
Additionally, the use of novel biomarkers for treatment monitoring and patient selection is expanding.
Emerging techniques under active investigation include:
- Intraoperative imaging
- Sentinel lymph-node biopsy
- Artificial intelligence applications