Navigating Anemia in Solid and Hematologic Malignancies: A Comprehensive Review of Classical and Emerging Therapies.

Journal: European journal of haematology

This publication is a narrative review focused on anemia in patients with cancer and its management.

It emphasizes that even mild-to-moderate anemia is clinically meaningful in oncology, contributing to:

  • Fatigue
  • Functional decline
  • Worse tolerance of systemic therapy
  • Poorer overall prognosis

It highlights that correcting anemia and improving hemoglobin can:

  • Reduce fatigue
  • Improve emotional well-being
  • Enhance overall quality of life

The authors summarize the current understanding of the mechanisms of cancer-related anemia, including disease- and treatment-related factors, and then review available therapeutic approaches.

  • Therapeutic approaches range from well-established supportive measures to newer, investigational, and targeted strategies.
  • The review is structured to move from conventional options to emerging therapies.
  • It distinguishes management considerations for patients with solid tumors versus hematologic malignancies.

The overarching goal is to provide a practical framework to help clinicians individualize anemia treatment in cancer care, with a strong focus on:

  • Quality-of-life improvement
  • Optimization of overall outcomes

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