Journal: International journal of cancer
This study evaluates public awareness of human papillomavirus (HPV) in relation to oropharyngeal squamous cell carcinoma (OPSCC) in Denmark and the projected clinical and economic burden of OPSCC.
Key points:
- HPV as a cause of OPSCC: HPV is a major cause of OPSCC, responsible for about 70% of cases in high‑income countries. OPSCC is currently the most common head and neck malignancy in Denmark.
- Survey of public awareness: A nationally representative cross‑sectional survey of 559 Danish adults (January 2025) assessed knowledge of HPV, its link to OPSCC, and attitudes toward vaccination.
- Incidence and economic projections: Registry data from 1980–2021 were used to calculate age‑adjusted OPSCC incidence trends and project incidence to 2039. These projections informed estimates of future economic burden, incorporating treatment costs and productivity losses.
- Increase in OPSCC incidence: From 1980 to 2021, OPSCC incidence rose 7.3‑fold in Denmark.
- Projected incidence in men: By 2039, the incidence among men is projected to reach 12.3 cases per 100,000 (95% CI 11.7–12.8).
- Economic burden: The cumulative economic burden of OPSCC between 2025 and 2039 is estimated at €2.23 billion (95% CI 2.12–2.33), with productivity losses constituting the majority of costs.
- Low public awareness: Public awareness is low: 38.5% of respondents had never heard of HPV, and only 37.0% recognized the association between HPV and OPSCC.
The study concludes that, despite rising incidence and substantial economic impact, HPV and its role in OPSCC are poorly understood by the public in Denmark, highlighting the need for broad educational efforts, awareness campaigns, and enhanced early detection strategies.