Journal: International journal of cancer
The study (DOI: 10.1002/ijc.70142) developed and validated a preoperative prediction model for early postoperative recurrence in pancreatic ductal adenocarcinoma (PDAC).
Data from 895 treatment-naïve patients who underwent direct resection were used. Early recurrence was defined as relapse within 6 months post-surgery.
The integrated clinical-radiomics model combines:
- Four clinical variables: gender, CA125, radiologic N stage, and adjuvant treatment
- Twenty-nine radiomic features extracted from preoperative CT scans
This model demonstrated strong predictive performance with AUCs of:
- 0.862 in the training set
- 0.843 in internal validation
- 0.848 in external validation
It outperformed models based on clinical or radiomic data alone.
High-risk patients identified by this model had significantly shorter disease-free and overall survival.
This tool enables personalized treatment planning by identifying PDAC patients at high risk for early recurrence prior to surgery.