Journal: Bone marrow transplantation
This publication offers expert consensus guidelines on the use of allogeneic hematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma, focusing on Mycosis Fungoides and Sézary Syndrome.
It addresses key clinical considerations including:
- Patient selection
- Timing
- Bridging therapies
- Donor choices
- Conditioning regimens
- Post-transplant care
The recommendations emphasize early referral to transplant specialists for patients with high-risk features such as:
- Advanced stage
- Large-cell transformation
- Refractory or relapsed disease
- N3 lymph node involvement
Early collaboration between dermatologists and transplant hematologists is highlighted as essential to avoid delays and improve survival outcomes.
These harmonized guidelines aim to standardize practice and enhance patient management in these aggressive lymphomas through multidisciplinary and evidence-based approaches.