Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
This publication reviews recent advances in the prevention and treatment of cytomegalovirus (CMV) infection in solid organ transplantation (SOT) and allogeneic hematopoietic cell transplantation (HCT).
It discusses new paradigms in:
- CMV risk assessment
- Antiviral therapies
- Immune-based strategies such as vaccination, monoclonal antibodies, and virus-specific T cells
The article also summarizes studies on CMV cell-mediated immunity assays, which help refine preventive and therapeutic approaches.
The review emphasizes enhancing CMV-specific immunity to reduce CMV-related complications across transplant settings.
It notes the emerging relevance of CMV management in recipients of CAR-T cell therapies and other immunocompromised groups.