Journal: British journal of haematology
This study presents a comprehensive global analysis of haematological malignancies in individuals aged 0-24 years, using data from 204 countries between 1990 and 2021.
It reports relatively stable global incidence and prevalence, with about 150,000 new cases and over one million prevalent cases in 2021. Notably, mortality and disability-adjusted life year (DALY) rates have significantly declined.
Key findings include:
- Leukemia remains the most common and impactful subtype, though most subtypes have seen reductions.
- Higher disease burdens were observed in males and in children under 5 years, with a secondary incidence peak in late adolescence.
- High-income regions showed higher incidence and DALYs but lower mortality.
- Lower socioeconomic regions faced greater lethality and disability.
The findings emphasize the need for targeted subtype-specific strategies, earlier diagnosis, and equitable treatment access to address ongoing disparities and improve outcomes worldwide.