Journal: Scientific reports
This nationwide population-based cohort study evaluated cancer risk in 2,150 patients with immunoglobulin G4-related disease (IgG4-RD) using the Korean National Health Insurance Service database.
Patients showed a significantly increased overall cancer risk (SIR 4.12), including:
- Solid tumors (SIR 3.33)
- Hematologic malignancies (SIR 15.31)
The highest risks among solid tumors were for:
- Pancreatic cancer
- Central nervous system cancer
- Biliary tract cancer
The most common hematologic cancers were:
- Myelodysplastic syndrome
- Non-Hodgkin lymphoma
Cancer risk was notably higher in females and peaked within the first year after IgG4-RD diagnosis.
These findings highlight the need for vigilant malignancy surveillance, especially early after diagnosis.