Journal: Nature reviews. Clinical oncology
This review addresses the challenges of applying CAR T cell therapy in solid tumors and highlights recent advancements aimed at improving efficacy and safety.
Key strategies discussed include:
- Careful target antigen selection to reduce off-tumor toxicity
- Early apheresis and rapid manufacturing to maintain T cell fitness
- Lymphodepletion to promote CAR T cell expansion
- Locoregional delivery for higher local drug concentration with lower systemic toxicity
- Repeat infusions to extend therapeutic benefit
The review also emphasizes the importance of advanced response evaluation methods and robust toxicity management to accurately assess treatment outcomes and mitigate severe adverse events.
This provides a practical framework for optimizing CAR T therapy in solid tumor settings.