Journal: Journal of the European Academy of Dermatology and Venereology : JEADV
This publication offers expert consensus recommendations on the use of allogeneic hematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma (CTCL), focusing on mycosis fungoides and Sezary syndrome.
It addresses key considerations such as:
- Patient selection
- Timing
- Bridging therapies
- Donor sources
- Conditioning regimens
- Post-transplant care
The guidelines emphasize early referral to transplant hematologists for high-risk patients, including those with:
- Advanced stage
- Large-cell transformation
- Relapsed or refractory disease
- Significant lymph node involvement
Early multidisciplinary collaboration is highlighted as essential to optimize transplant timing and improve patient survival. These guidelines aim to standardize clinical practice and enhance outcomes.