TP53 p.R181H is enriched in the Swedish cohort (SWEP53) and associated with a distinct breast and prostate phenotype.
This study characterizes the TP53 variant p.R181H within a Swedish Li-Fraumeni Syndrome (LFS) cohort, revealing it as a...
Functional characterization of BRCA1 variants of unknown significance using homologous recombination repair assays.
- Post category:Breast Cancer
- Reading time:1 min read
This study evaluated 16 BRCA1 variants of uncertain significance (VUS) identified in a hereditary cancer genetic counsel...
Phase Ib Basket Expansion Trial and Alternative-Schedule Dose-Escalation Study of ATR Inhibitor Elimusertib in Advanced Solid Tumors with DNA Damage Response Defects.
- Post category:Breast Cancer
- Reading time:1 min read
This phase Ib trial evaluated the ATR inhibitor elimusertib in 143 patients with advanced cancers exhibiting DNA damage...
Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes.
- Post category:Breast Cancer
- Reading time:1 min read
This study presents an updated meta-analysis examining the association between rare genetic variants identified through...
The Honest Broker: Reimagining the Roles of Health Services Research, Community Partnership, and Policymaking to Address Structural Determinants of Cancer Outcomes.
- Post category:Breast Cancer
- Reading time:1 min read
This commentary highlights the evolution of health disparities research over the past 50 years, shifting from focusing o...
Critical Evaluation of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.
- Post category:Breast Cancer
- Reading time:1 min read
The publication presents a study evaluating the efficacy and safety of a novel treatment approach in patients with advan...