TP53 p.R181H is enriched in the Swedish cohort (SWEP53) and associated with a distinct breast and prostate phenotype.
This study characterizes the TP53 variant p.R181H within a Swedish Li-Fraumeni Syndrome (LFS) cohort, revealing it as a...
AI assessment of tumor-infiltrating lymphocytes on routine H&E-slides as a predictor of response to neoadjuvant therapy in breast cancer-a real-world study.
- Post category:Breast Cancer
- Reading time:1 min read
This study evaluates tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers in triple-negative (T...
Functional characterization of BRCA1 variants of unknown significance using homologous recombination repair assays.
- Post category:Breast Cancer
- Reading time:1 min read
This study evaluated 16 BRCA1 variants of uncertain significance (VUS) identified in a hereditary cancer genetic counsel...
Phase Ib Basket Expansion Trial and Alternative-Schedule Dose-Escalation Study of ATR Inhibitor Elimusertib in Advanced Solid Tumors with DNA Damage Response Defects.
- Post category:Breast Cancer
- Reading time:1 min read
This phase Ib trial evaluated the ATR inhibitor elimusertib in 143 patients with advanced cancers exhibiting DNA damage...
Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes.
- Post category:Breast Cancer
- Reading time:1 min read
This study presents an updated meta-analysis examining the association between rare genetic variants identified through...
The Honest Broker: Reimagining the Roles of Health Services Research, Community Partnership, and Policymaking to Address Structural Determinants of Cancer Outcomes.
- Post category:Breast Cancer
- Reading time:1 min read
This commentary highlights the evolution of health disparities research over the past 50 years, shifting from focusing o...